Synthesis and complex-forming properties of thiazolyl-containing organophosphorus complexone

Abstract

Alkaline hydrolysis of the previously prepared ethyl 2-methyl-2-[diethylamido-N-(4′-phenylthiazolyl-2-amido)phosphono]glycidate and 2-phenyl-2-[diethylamido-N-(4-phenylthiazolyl-2-amido)phosphono]glycidate accompanied by decarboxylation in situ of the obtained glycidic acids furnished 2-[diethylamido-(4′-phenylthiazolyl-2′-amido)phosphono]propionic and 2-phenyl-2-[diethylamido-(4′-phenylthiazolyl-2′-amido)phosphono]acetic aldehydes. The qualitative and quantitative evaluation of complex-forming ability of the compounds obtained with respect to transition metal ions was carried out. For identification of copper complex the evaluation of the stability constants of copper, cobalt, nickel, and zinc complexes was performed. Thermodynamic parameters of complex formation reactions were calculated. Correlation dependences between the physicochemical properties of metal ions and thermodynamic characteristics of complex formation with the organophosphorus ligands obtained were established.