Regulation of TGFβ/SMAD signaling by long non-coding RNAs in different cancers: Dark Knight in the Castle of molecular oncology
| dc.contributor.author | Adylova, A. | |
| dc.contributor.author | Mukhanbetzhanovn, A. A. | |
| dc.contributor.author | Attar, R. | |
| dc.contributor.author | Yulaevna, I. M. | |
| dc.contributor.author | Farooqi, A. A. | |
| dc.date.accessioned | 2022-03-11T08:22:18Z | |
| dc.date.available | 2022-03-11T08:22:18Z | |
| dc.date.issued | 2021-03 | |
| dc.description.abstract | One of the complex themes in recent years has been the multi-layered regulation of TGF beta signaling in cancer cells. TGF beta/SMAD signaling pathway is a highly complicated web of proteins which work spatio-temporally to regulate multiple steps of carcinogenesis. TGF beta/SMAD has been shown to dualistically regulate cancer progression. Therefore, TGF beta/SMAD signaling behaves as a "double-edged sword" in molecular oncology. Accordingly, regulation of TGF beta/SMAD is multi-layered because of oncogenic and tumor suppressor long non-coding RNAs (LncRNAs). In this review, we have summarized most recent breakthroughs in our understanding related to regulation of TGF beta/SMAD signaling by lncRNAs. We have comprehensively analyzed how different lncRNAs positively and negatively regulate TGF beta/SMAD signaling in different cancers. We have gathered missing pieces of an incomplete jig-saw puzzle of lncRNA-interactome ranging from "sponge effects" of lncRNAs to mechanistic modulation of TGF beta/SMAD signaling by lncRNAs. | ru_RU |
| dc.identifier.citation | Regulation of TGFβ/SMAD signaling by long non-coding RNAs in different cancers: Dark Knight in the Castle of molecular oncology/ Adylova A. [et al.] // Non-coding RNA Research. - 2021. - Vol. 6 (1). P.23-28. | ru_RU |
| dc.identifier.issn | 2468-2160 | |
| dc.identifier.uri | https://rep.buketov.edu.kz//handle/data/11995 | |
| dc.language.iso | en | ru_RU |
| dc.publisher | Non-coding RNA Research | ru_RU |
| dc.relation.ispartofseries | Non-coding RNA Research;№6 (1) | |
| dc.subject | Cancer | ru_RU |
| dc.subject | Oncology | ru_RU |
| dc.subject | Carcinogenesis | ru_RU |
| dc.subject | Signaling | ru_RU |
| dc.subject | Non-coding RNAs | ru_RU |
| dc.title | Regulation of TGFβ/SMAD signaling by long non-coding RNAs in different cancers: Dark Knight in the Castle of molecular oncology | ru_RU |
| dc.type | Article | ru_RU |