Modeling the extraction process of medicinal raw materials

Abstract

The review considers 26 mathematical models of the process of biologically active substances extraction from medicinal plant raw materials, taking into account factors affecting the extraction process: diffusion coefficient, particle size, layer porosity, extractant feed rate, raw material grinding method, pressure, temperature and duration of extraction, individual characteristics of raw materials (content of the target component) and technological equipment. In general, these models fall into four important groups: empirical models, models based on heat transfer analogies, a shrinking core model, and models based on differential mass balance. Here were described problems that occur in the selection of mathematical models, first of all, associated with the imperfect behavior of the flows of extraction liquids, and the inhomogeneous cross-section of the extraction apparatus. It was shown that first of all the extraction process modeling requires mathematical models to describe the mass transfer inside solid particles. It is also important to take into account the solubility of the target substances when simulating. It is shown that for describing the extraction processes, the optimal models are Naik and Lentz, Esquivel, diffusion, H. Sovová mass transfer, damaged and undamaged cells for calculating the main factors of extraction processes.