Diabetogenic derivatives of 8-oxyquinolin (mechanisms of action and principles for prevention developing of diabetes caused by them)

Abstract

Alteration and destruction of pancreatic B-cells caused by chemicals are one of numerous causes of developing of diabetes mellitus. Authors demonstrated results of investigation of mechanisms developing of diabetes caused by some of 18 diabetogenic derivatives of 8-oxyquinolin including chemicals formed in Human as result of disturbances of metaboilsm of aminoacids. Authors proposed a few ways for prevention of diabetes developed as result of their action and proposed for possible using of method inhibition of endogene synthesis of diabetogenic metabolites of Tryptophan as more suitable way for prevention developing of diabetes.