Vascular changes in pancreas in diabetes caused by abnormal metabolits of tryptophan aggravate developing of diabetes

Abstract

Contrary to many models of experimental diabetes caused by chemicals, diabetes induced by endogene synthesis of xanturenic acid (XA), a metabolit of abnormal Tryptophan metabolism, approached to human diabetes. Meanwhile in these conditions of natural developing of diabetes not in result of artificial injection of diabetogenic substances, are not investigated yet state of blood vessels and blood circulation as in exocrine pancreas tissue as in pancreatic islets. Authors showed developing in experimental XA-diabetes of numerous destructive changes of blood vessels of a pancreas, fibrinoid changes of parenchyma of pancreas tissue,dystrophya and necrosis of exocrine and endocrine pancreas tissue; necrotic changes of endothelium of arteries. In pancreatic islets: necrosis of endothelium and cells in pericapillar. Authors conclude that described changes can result aggravation of developing of diabetes.