Concentration of complex Zn+2–chelator around blood vessels in pancreatic islets result alteration and destruction of capillaries

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dc.contributor.authorMeyramov, G.G.
dc.contributor.authorKohnert, K.-D.
dc.contributor.authorWilliams, A.A.
dc.contributor.authorKikimbaeva, A.A.
dc.contributor.authorTurgunova, L.G.
dc.contributor.authorTyrzhanova, S.S.
dc.contributor.authorAlina, A.R.
dc.contributor.authorShaybek, A.Zh.
dc.contributor.authorAbdullina, G.A.
dc.contributor.authorZhuzbaeva, G.O.
dc.contributor.authorKovalenko, O.L.
dc.contributor.authorMeyramova, A.G.
dc.date.accessioned2019-04-08T06:35:44Z
dc.date.available2019-04-08T06:35:44Z
dc.date.issued2014-12-30
dc.description.abstractAuthors showed that concentration around capillaries wall of complex Zn+2-chelator formed in result of interaction in cytoplasm of B-cells of Zn+2-ions with diabetogenic zincbinding chelators is one of causes of developed vascular changes in capillaries of pancreatic islets. These changes as alteration of basal membrane of capillaries, edema of endothelium, partial destruction of capillaries wall and hyperemia can to aggravate developing of degenerative changes in pancreatic islets induced by Zn+2-chelator that result aggravation developing of diabetes. Meanwhile main cause of developing of diabetes induced by zincbinding chelators is its ability to form toxic complexes with Zn+2-ions in B-cells that result necrosis and destruction of B-cells within short time.ru_RU
dc.identifier.citationMeyramov, G.G., Kohnert, K.-D., Williams, A.A., Kikimbaeva, A.A., Turgunova, L.G., Tyrzhanova, S.S., Alina, A.R., Shaybek, A.Zh., Abdullina, G.A., Zhuzbaeva, G.O., Kovalenko, O.L., Meyramova, A.G. Concentration of complex Zn+2–chelator around blood vessels in pancreatic islets result alteration and destruction of capillaries/G.G.Meyramov [et al]//Қарағанды университетінің хабаршысы. Биология. Медицина. География сериясы = Вестник Карагандинского университета. Серия Биология. Медицина. География. - 2014. №4. С.96-100ru_RU
dc.identifier.issn0142-0843
dc.identifier.urihttps://rep.buketov.edu.kz:80//handle/data/4901
dc.language.isootherru_RU
dc.publisherPub KSUru_RU
dc.relation.ispartofseriesҚарағанды университетінің хабаршысы. Биология. Медицина. География сериясы = Вестник Карагандинского университета. Серия Биология. Медицина. География.;№4(76)/2014
dc.subjectpancreatic isletsru_RU
dc.subjectinsulin, Zn+2-ionsru_RU
dc.subjectB-cellsru_RU
dc.subjectdestructionru_RU
dc.subjectblood vesselru_RU
dc.subjectchelat complexesru_RU
dc.subjectvascular changesru_RU
dc.subjectdiabetogenic derivatives of 8-oxyquinolinru_RU
dc.titleConcentration of complex Zn+2–chelator around blood vessels in pancreatic islets result alteration and destruction of capillariesru_RU
dc.title.alternativeҚылтамырлар қабырғасының бұзылуымен қоса жүретін панкреатиттік аралшықтардағы қылтамырлар маңайындағы «Zn+2–хелатор» кешенінің қалыптасуыru_RU
dc.title.alternativeФормирование комплекса «Zn+2–хелатор» вокруг капилляров в панкреатических островках, сопровождающееся деструкцией их стенкиru_RU
dc.typeArticleru_RU

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4(76)/2014 - Биология. Медицина. География