Interaction of d-treo-2-methylamino-1-phenyl-1-propanol with 4-morpholylbenzaldehyde in the conditions of convectional heating and microwave activation

Abstract

The synthesis of 1,3-oxazolidine was made by condensation reaction of d-treo-2-methylamino-1-phenyl-1- propanol with 4-(N-morpholyl)-benzaldehyde under the conditions of convectional and microwave activation. The structure of 1,3-oxazolidine has been proved by IR- and 1Н NMR-spectroscopies. Physico-chemical constants of the oxazolidine obtained by both methods were identical. 4-(N-morpholyl)-benzaldehyde, 4-(4- ((4R,5R)-3,4-dimethyl-5-phenyloxazolidine-2-yl)phenyl)morpholine obtained very promising in terms of learning conformational features of the structure and biological properties. The structure of the new heterocyclic compounds — 4-(N-morpholyl)-benzaldehyde, 4-(4-((4R,5R)-3,4-dimethyl-5-phenyloxazolidine-2-yl)- phenyl)morpholine is proved by data IR and NMR 1H spectroscopy, as well as a comparative study of the influence of convection and microwave heating on the yield and character formation of the final product has been made.