Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells

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dc.contributor.authorMukusheva, G.K.
dc.contributor.authorJalmakhanbetova, R.I.
dc.contributor.authorShaibek, A.Zh.
dc.contributor.authorNurmaganbetova, M.S.
dc.contributor.authorZhasymbekova, A.R.
dc.contributor.authorNurkenov, O.A.
dc.contributor.authorAkishina, E.A.
dc.contributor.authorKolesnik, I.A.
dc.contributor.authorDikusar, E.A.
dc.contributor.authorTerpinskaya, T.I.
dc.contributor.authorKulchitsky, V.A.
dc.contributor.authorPotkin, V.I.
dc.contributor.authorPushkarchuk, A.L.
dc.contributor.authorLyakhov, D.A.
dc.contributor.authorMichels, D.L.
dc.date.accessioned2025-01-13T06:19:31Z
dc.date.available2025-01-13T06:19:31Z
dc.date.issued2024
dc.description.abstractAlkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cellsru_RU
dc.identifier.citationAlkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells/Mukusheva G.K. [et al.] //Molecules. - 2024 - Vol 29(3246.). - pp.1-16.ru_RU
dc.identifier.urihttps://rep.buketov.edu.kz//handle/data/19384
dc.language.isoenru_RU
dc.publisherMoleculesru_RU
dc.subjectanabasineru_RU
dc.subjectcytisineru_RU
dc.subjectureasru_RU
dc.subjectisoxazoleru_RU
dc.subjectcytotoxic activityru_RU
dc.subjectantiproliferative activityru_RU
dc.subjectdrug synergismru_RU
dc.subjectquantum chemical modelingru_RU
dc.subjectmolecular dockingru_RU
dc.titleAlkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cellsru_RU
dc.typeArticleru_RU

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