Synthesis and growth regulatory activity of guaianolide estafiatine and its derivatives

Abstract

In this work, methods for directed synthesis of practically significant derivatives of guaianolide estafiatine were considered. It is shown that α-epoxy cycle, which is present in the molecule of estafiatine determines the stereo — and regioselectivity of nucleophilic addition and obtaining new biologically active derivatives. Discussed in this paper sesquiterpene lactone estafiatine and its derivatives were studied in terms of obtaining new biologically active compounds and the influence of structural features of the molecules of this series on their biological activity. During of performed bio-experiments, growth regulatory activity of series of estafiatine derivatives was found.