Glycidol esters from diethylamido-(4-phenylthiazolyl-2-amido)-ketophosphonates and their chemical modification

Abstract

Thiazolyl-containing esters of alpha-ketophosphonic acids (KPE) unknown earlier were synthesized and investigated in Darzens-Claisen reaction. Reactions were demonstrated to proceed by a classic scheme to form the corresponding phosphorylated glycidol esters whose alkaline hydrolysis gave rise to phosphorylated aldehydes of interesting nature.