Nanoparticles on the basis of polylactic acid and polylactic-co-glycolic acids loaded with drugs

Abstract

In this article a brief review on the research works devoted to the synthesis and investigation of polymeric nanoparticles and nanocapsules on the basis of polylactic acid and its copolymer with polyglycolic acid is given. Nanoparticles based on biocompatible and biodergadable polylactic acid and polylactic-co-glycolic acids gained special interest in pharmaceutical field as the carriers of different drug preparations. General methods of synthesizing nanosomal formulations of polylactic acid and polylactic-co-glycolic acids were described in this work. Among the perspective methods of obtaining the polymeric nanoparticles and nanocapsules of polylactides and its copolymer with glycolic acid loaded with drugs the nanoprecipitation and emulsion methods were found to be the most suitable for the systems used. Another method of synthesizing the nanosized systems of polylactic-co-glycolic acid is a double emulsion method which makes possible to obtain nanocapsules with optimal characteristics. The possibilities of immobilization of nanoparticulate systems based on these polymers with antitumor and antituberculosis drugs were considered. Some examples of polylactic acid and polylactic-co-glycolic acids’ nanoparticles and nanocapsules loaded with drugs which have applications in medicine for the treatment of tumor and tuberculosis diseases were shown.