Reactions of tert-butyl tetraethylphosphorodiamidite with acetic and trifluoroacetic acids

Abstract

Reactions of tert-butyl tetraethylphosphorodiamidite with acetic and trifluoroacetic acids involve substitution of the amido group. This process was described by a scheme beginning with protonation of phosphorus and proved by modeling separate reaction stages. A probable scheme of the proposed reactions is described.