Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins

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dc.contributor.authorTemirgaziyev, B.S.
dc.contributor.authorKučáková, K.
dc.contributor.authorBaizhigit, Y. A.
dc.contributor.authorJurášek, M.
dc.contributor.authorDžubák, P.
dc.contributor.authorHajdúch, M.
dc.contributor.authorDolenský, B.
dc.contributor.authorDrašar, P.B.
dc.contributor.authorTuleuov, B.I.
dc.contributor.authorAdekenov, S.M.
dc.date.accessioned2019-03-09T04:04:53Z
dc.date.available2019-03-09T04:04:53Z
dc.date.issued2018
dc.description.abstract20-Hydroxyecdysterone – (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. By studying the changes in chemical shifts of protons of substrates and receptors it was found that ecdysterone interacts with cyclodextrins to form supramolecular inclusion complexes of stoichiometric composition of 1:1 or 1:2. Ecdysterone-β-cyclodextrin complexes exhibit 100 times higher solubility in water than the parent compound.ru_RU
dc.identifier.citationBioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins/B. S. Temirgaziyev[a.o.]ru_RU
dc.identifier.urihttps://rep.buketov.edu.kz:80//handle/data/4128
dc.language.isoenru_RU
dc.publisherElsevier Inc.ru_RU
dc.subjectEcdysteronesru_RU
dc.subjectCyclodextrinsru_RU
dc.subjectInclusion complexesru_RU
dc.subjectNMR spectroscopyru_RU
dc.titleBioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrinsru_RU
dc.typeArticleru_RU

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