Study of degree of basicity of 2-amino 4-phenylthiazole and 2-amino-4-oxothiazole by mineral acids protonation

Abstract

There was studied protonation of aminothiazoles of mineral acids of different strength in order to research the basicity of nitrogen atoms of free amino group and nitrogen of thiazole ring. The results obtained showed high ambidentity of 2-amino-4-phenylthiazole and 2-amino-4-oxothiazole associated with a high degree of delocalization of both the lone pair of electrons of the amino group and the thiazole ring nitrogen atom which creates opportunities for chemical modification of the aminoheterocycles with the free amino group and the ring nitrogen atom. Сomplexing ability of 2-amino-4-oxothiazole with cobalt (II) chloride caused by high degree of basicity of cyclic nitrogen atom was also studied.