Synthesis, mechanism of formation and spatial arrangement of (2S,3S,6R)-2,6-diphenyl-3,4-dimethyl-6-ol

Abstract

Alkylation of alkaloid D-pseudoephedrine with bromoacetophenone results in a morpholine derivative. Structural and energy characteristics of the molecules of the starting, intermediate, and final reaction products were calculated by ab initio method in the HF/6-31G(d,p) approximation. The spatial structure of the final reaction product was determined by X-ray diffraction analysis.