Polyelectrolytic multilayers as drug delivery system

Abstract

This article is devoted to preparation of polyelectrolytic microcapsules of two antitubercular drugs (ATDs) as the new drug delivery system (DDS). Co-encapsulation of oral antitubercular drugs pyrazinamide and moxifloxcin by polyelectrolytic multilayers is carried out for the first time. At first by ionotropic gelation method co-encapsulation of drugs to a polymeric matrix carried out. As a matrix biopolymers gellan and sodium alginate were used. The co-encapsulation efficiency was determined using UV-spectroscopy method as it is specified in the State pharmacopeia of the Republic of Kazakhstan. Then by the method of fiber adsorption (LbL-technique — Layer by layer deposition) on microcapsules sequentially coated a cationic polyelectrolyte chitosan and an anionic polyelectrolyte eudragit S100. The charge of each layer was determined by zeta-potential measurement. Microcapsules about 3, 5 and 10 bilayers of polyelectrolytes are prepared. The structure of microcapsules was studied by method of the scanning submicroscopy. In vitro drug release studies carried out at values рН, modeling various sites of digestive tract. As a result of a research it is shown that microcapsules possess the prolonged action. With increase in number of bilayers extent of prolongation of drugs increases. It is enough 5 bilayers of polyelectrolytes to achieve the 24th hour prolongation of drugs.