State of histostructure of liver and of exocrine pancreas tissues in experimental diabetes caused by diabetogenic metabolites of tryptophan

Abstract

Authors showed new experimental data on the state of histostructure of Liver and Exocrine Pancreas tissue in experimental diabetes approached on conditions of development to human 2 type diabetes caused by 4,8-dihydroxyquinolin-2-carboxylic acid — the substance actively synthesized in elderly human, unlike all known today more than 30 diabetogenic substances. It is established that, at the same time with destruction of pancreatic B-cells that is a direct cause of diabetes, a multiple destructive changes are developed in a Liver and in Exocrine tissue of Pancreas. Authors suppose these changes which are not belong to direct causes of developed diabetes, but can aggravate diabetes considerably.